Amani Sereni, 48, was last seen leaving the 3200 block of Winbern Street near Alabama, not far from Yates High School, on Oct. 7.
Sereni was wearing a blue dress shirt and blue pants.
He's 6'5" and 185 pounds.
Sereni's spouse tells ABC13 it's not like him to disappear.
If you have any information, you're asked to contact Houston police patrol at 713-884-3131 or the Houston Police Missing Persons Division at 832-394-1840.