Amani Sereni, 48, was last seen leaving the 3200 block of Winbern Street near Alabama, not far from Yates High School, on Oct. 7.
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Sereni was wearing a blue dress shirt and blue pants.
He's 6'5" and 185 pounds.
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Sereni's spouse tells ABC13 it's not like him to disappear.
If you have any information, you're asked to contact Houston police patrol at 713-884-3131 or the Houston Police Missing Persons Division at 832-394-1840.