Authorities issued the alert Friday afternoon but discontinued it a few hours later.
Authorities said they were looking for 11-month-old Jayden Lee Lopez; 4-year-old Jordan Lopez; 7-year-old Ruben Lopez Jr.; 9-year-old Jolyne Kaylynn Lopez, and 10-year-old Justine Kaylee Lopez.
The children were last seen Aug. 10 at 11:25 a.m. in Crystal City, Texas, according to authorities.
Police said the kids were with 29-year-old Ruben Lopez and 31-year-old Roxanne Fuentes.
Ruben is described as a white male who is 5-feet, 6-inches tall with black eyes and brown hair. Fuentes is described as a white woman who is 5-feet, 8-inches tall, weighs 120 pounds and has black eyes and brown hair.
The suspects were seen driving a grey 2008 Chevy Trail Blazer with Texas license plate MKV2702.