According to officials, a vehicle ran the stop sign, which caused the driver to over-correct the turn and crash into the home around 7:30 p.m.
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No one was inside the home, METRO officials said.
Homeowner Darrell Parker found out about the accident after a neighbor called.
"I couldn't believe it," he said.
Parker told ABC13's Deborah Wrigley that he rushed back to his home as fast as he could.
"I'm still in a bit of shock," he added. "I don't believe this."
Kirk Williams said he witnessed the accident.
"I was waiting for a ride, and I saw the car run the stop sign and hit the bus. It crashed into the house," Williams said. "I told people to call 911 and ask for ambulances."
The bus operator and three passengers were taken to nearby hospitals with non-life threatening injuries.
No other details have been released.
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