According to Sugar Land police, the men were walking on the train tracks near University when they were hit.
One of the men was taken by ambulance to a nearby hospital, while the second was taken via Life Flight to another hospital.
Again, the extent of their injuries is not known.
The train is currently stopped, blocking traffic of Highway 6 and US-90.
Stay with ABC13 Eyewitness News for more on this developing story.
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