The shooting happened around 12:45 a.m. Monday at 5906 Werner Street, according to Houston police.
Neighbors called 911 and said they heard gunshots outside.
When officers arrived, they found a man collapsed with multiple gunshot wounds in front of a home. He was pronounced dead at the scene.
Investigators said the man doesn't live at the home, and they're not sure if he was running to the home's front yard when he collapsed.
Police were working to find surveillance video in the area.
Anyone with information is urged to contact the HPD Homicide Division at 713-308-3600 or speak anonymously to Crime Stoppers at 713-222-TIPS.