The Houston Police Department responded to reports of a shooting outside a business near Emancipation and Blodgett around 1 a.m.
Investigators say an argument broke out between two men, and minutes later, one of the men fired three to five shots, killing a man.
The gunman was last seen running north on Emancipation.
Anyone with information is asked to call Crime Stoppers at 713-222-TIPS (8477), submit online at www.crime-stoppers.org or through the Crime Stoppers mobile app. All tipsters remain anonymous.