The Houston Police Department said officers responded to a shooting in the 1300 block of Chartres Street just before 8 p.m.
According to HPD, a man was riding a bike down the street when gunfire erupted.
In an update, police said the man who was shot was taken to the hospital in critical condition, where he later died.
Investigators said two men driving along Chartres Street stopped to help the victim but did not see what happened.
It is unclear what led up to the shooting. Officers have not released a description of any possible suspects.
No arrests have been made, and police said they don't believe anyone was at the scene to witness the deadly shooting.
For updates on this story, follow Briana Conner on Facebook, Twitter and Instagram.