Houston police were called to the Royal Palms Apartments at 5601 Royal Palms Street near Griggs Road at 12:30 a.m. Thursday.
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A young man received a call to go check on the victim, and when he arrived, he noticed the door to the apartment was open, HPD said.
When he went inside, he found the victim unresponsive on the floor in a bedroom and quickly called 911.
Although HPD initially said the man had been shot, in a later update, officials said the 49-year-old victim had an apparent stab wound to the chest. He was pronounced dead at the scene.
Investigators said no weapons were found at the scene.
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The victim lives at the apartment with a woman, who was not there when police arrived.
Investigators are calling her a person of interest and want to talk to her, though they don't know if she may also be a victim.
HPD described her only as a Black female.
Police were working to get surveillance video from the apartment complex.
Anyone with information on this case or on the female being sought for questioning is urged to contact the HPD Homicide Division at 713-308-3600 or speak anonymously to Crime Stoppers at 713-222-TIPS.