Officers were called to the Red Roof Inn off West Sam Houston Parkway and Westheimer Road just before 10 p.m.
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Authorities said the two men were arguing when the suspect got out a gun.
"Our suspect just reaches into a bag, pulls out a pistol, shoots him one time, our (victim) goes down. He shoots him a couple more times, and as he's walking off, shoots a few more times. It looks like he hit him every time," said Lt. R. Willkens with Houston police.
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Police believe they know who the suspect is, but they have not made an arrest.