San Antonio police said they responded at about 10:30 a.m. Tuesday to reports of gunshots off Medina Base Road.
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At about 10:54 a.m., officials tweeted they were on lockdown but there was no threat to anyone residing on the base.
Several facilities had been shut down to allow security forces to complete operations.
In an update at 11:09 a.m., a gate still remained closed, as officials were "continuing to work with SAPD to ensure a safe environment."
"In times like these, with the events that have happened recently, we want to take these type of situations very seriously," Cmdr. Brig. Gen. Russell D. Driggers said, alluding to the multiple mass deadly shootings across the U.S.
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In a briefing, Driggers said the base was given an all-clear at 11:34 a.m.
It was unknown if anyone was taken into custody.
"We take the safety and security of everyone on our base, and in the local community, very seriously," Driggers said.