Two other teens were taken to the hospital by ambulance with minor injuries.
According to police, a 15-year-old girl stole her mother's car and went joyriding with three other juveniles in an apartment complex around 2:20 a.m.
Investigators say the teenager lost control of the vehicle, striking a tree near Memorial Park.
Officers said one teen was transported by Life Flight to Memorial Hermann with a serious head injury. Another two juveniles were taken to Bayshore Hospital with non-life threatening injuries.
Police are working on trying to find the parents of the teens.
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