Jennifer Ann Scott-Perkins, 48, left her home on Jan. 2 and has not been seen since leaving a friend's home in the town of Shepherd, located about 60 miles northeast of Houston.
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Houston police said Perkins made several phone calls near Highway 146 and Highway 787 near Rye, in north Liberty County.
According to investigators, Perkins sounded upset during a call made just before she disappeared.
She was last seen driving a gray colored 2012 Chrysler 200 with Texas license plate LJK0423.
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Perkins is described as a white female, 5'2", 140 pounds, with blonde hair down to the middle of her back, usually worn in a ponytail braid. She has green eyes and several tattoos on her arms and back.
She was wearing a pink hat, tights, boots and a thin black or gray jacket when she disappeared.
If you know where she is or have seen her, call Houston police at 713-308-3600, the Liberty County Sheriff's Office at 936-336-4500 or Texas EquuSearch at 281-309-9500.