Thomas' agent, Don Buchwald, confirmed the actor's death from cancer in a statement.
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"Jay was one of a kind, never at a loss for words and filled with so much fun and wonderfully whacky thoughts and behavior," the statement read.
No other details of his death were released.
A Texas native, Thomas broke into television playing Remo DaVinci on "Mork & Mindy." He later landed a recurring role as the hockey-playing husband of Rhea Perlman's character on "Cheers."
He won back-to-back Emmys in 1991-92 for the guest role on "Murphy Brown," playing outspoken talk-show host Jerry Gold.
Thomas had a recurring role on "Ray Donovan" and he made a 2105 guest appearance on "Bones." He appeared in a series of films over the years, including "Mr. Holland's Opus."
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Thomas worked briefly at KISS in Boston before being hired by then new Rhythmic Top 40 KPWR/Los Angeles as their new morning host, where he enjoyed a successful 10-year run, according to a bio on Thomas' website.
While in Hollywood, Thomas' campaign "We apologize for Jay Thomas on Power 106-fm" was seen all around town.
Most recently, Thomas hosted a talk show on SiriusXM.
City News Service contributed to this report.