It happened just before 4 a.m. at the James Avery location in the 14000 block of E. Sam Houston Parkway in northeast Harris County.
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Deputies said the suspects, who were wearing masks, drove a black Ford F-250 into the store and smashed several display cases.
They took some items and were in and out within a minute, deputies say.
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It's not clear what was taken or how much.
James Avery released the following statement to ABC13 about the burglary:
"Last night, our James Avery Artisan Jewelry store in Westlake Marketplace was burglarized. We are grateful that all of our associates and customers are safe. The matter is now in the hands of the authorities. The store will be closed today for repairs and we are working to reopen as soon as possible. Customer owned items in the store are safe and secure. All other Houston area stores are open regular business hours today. Kingwood Commons, the Market at Crenshaw in Pasadena and Baytown Plaza are the locations nearest to our Westlake store."
Follow ABC13 Reporter Courtney Fischer on Twitter and Facebook.