Authorities say a piece of heavy equipment flipped onto both men around 9 p.m. Thursday at Spitzer Industries, located in the 13800 block of Industrial Road near the Houston Ship Channel.
One man died at the scene, and the second died at the hospital. A third person was treated at the scene.
The Harris County Medical Examiner's Office identified the victims as Eric Rojas and Isidro Cadrea Mendoza.
The company calls itself a leading custom steel fabricator.
It's based in Houston and the facility, which it calls its Waterfront Facility, "provides a direct link to the Houston Ship Channel, enabling worldwide shipment of large components."
ABC13 has reached out to Spitzer Industries for comment.