The Houston Police Department said its North Patrol and Vehicular Crimes Division officers were called to the crash site near West Gulf Bank.
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Houston TranStar verified the incident at 6:48 p.m. with two vehicles involved. The lanes impacted include two frontage road lanes and the Highway 249/Mount Houston exit ramp.
Police offered no other details other than to warn drivers to expect delays.
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A photo taken at the scene shows multiple HPD vehicles, as well as an extermination company's pickup. Police did not mention whether the pickup was involved in the crash.