Houston police said the bodies of two men were found at the end of a standoff that lasted for seven hours in the 5200 block of Arboles Drive, near Chimney Rock and West Bellfort.
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Police took the suspect into custody.
According to police, the Hispanic men who died were among the seven people inside the home, including the suspect, during the reported siege.
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Over the course of the ordeal, two other people escaped through a window, while another two got out through a back door of the apartment unit.
Police suspected the deaths were due to drug overdoses. They added the deaths will be conducted as a murder investigation.
Details of the suspect, including the person's identity and charges, were not immediately disclosed.