The crash, which was located on the northbound I-45 North Freeway after Parramatta Lane, involved three vehicles and it was verified at 5:30 p.m., according to Houston TranStar.
All main lanes, the left shoulder, and the right shoulder on the northbound side were blocked. The southbound I-45 was also impacted, with the left shoulder and two main lanes obstructed as well.
SkyEye captured multiple first-responding emergency vehicles taking up lanes in both directions. A heavily-damaged white vehicle was also seen at rest against the northbound right shoulder.
It's not immediately known how many people were injured or killed.
This is a developing story. All updates can be found in this article or on ABC13 Houston's 24/7 Streaming Channel.