It happened sometime before 8:30 p.m. on the freeway at Bingle Road. At least five vehicles were involved, according to Houston TranStar.
The pedestrian was transported to a hospital where they later died, Houston police said.
Traffic on 290 was stacked up for more than two miles before the crash scene for several hours while crews worked to investigate what happened.
Drivers had to detour via the feeder road, which was also heavily congested. Gessner Road and Hempstead Road or West Little York Road served as viable alternate routes.
The crash happened before West 43rd Street.
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