Houston police said they were called at 1 p.m. on Monday about a crash on the interstate. At the scene, officers reported finding the motorcycle driver pinned under a red Dodge Durango.
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Authorities said the car driver has been transported to the hospital.
Traffic cameras show several blocked lanes are causing delays and forcing drivers to use the HOV and three left lanes.
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The incident occurred at a major interchange that caused a backup from Beltway 8 to Spring Valley with multilane delays.