Houston TranStar verified the incident at 5:41 p.m. on Highway 225, which is otherwise known as the LaPorte Freeway, at Allen Genoa Road.
The incident involved three vehicles, and all mainlanes and both shoulders were affected, Houston TranStar stated.
It's not immediately known what exactly happened, or what caused the wreck.
Houston police acknowledged the crash, tweeting that their Eastside, Vehicular Crimes Division, and Mobility officers were on scene.
Texas Department of Transportation reported the crash was cleared at 8:43 p.m.