Harris County sheriff's deputies were called to a report of a single-vehicle crash in the southbound exit lane of State Highway 99 at 4:41 p.m., Sheriff Ed Gonzalez tweeted.
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The sheriff said a 16-year-old girl was behind the wheel and a male passenger who may be 17 years old were critically injured.
The girl was flown to the hospital by Life Flight while the passenger was taken by ambulance.
Authorities did not say what led up to the wreck.
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