The crash was reported near Fuqua Street, just north of Beltway 8, at 6:15 a.m.
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All southbound lanes were closed, causing major delays for drivers headed toward Hobby Airport. All mainlanes reopened at 9:21 a.m.
SkyEye flew over the scene before the roadway reopened, where bumper-to-bumper traffic stretched all the way past the I-610 South Loop.
It's unclear exactly what led up to the deadly crash.
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