The crash was reported at about 7:08 a.m. on Eastex Freeway southbound near Lauder Road, according to the Harris County Sheriff's Office.
Photos and video from the scene showed the cab of the 18-wheeler upside down on the shoulder of the freeway with the smashed trailer on the feeder road below.
It's unclear what exactly led up to the crash.
Authorities said one person was taken to the hospital.
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