The crash was reported at about 7:08 a.m. on Eastex Freeway southbound near Lauder Road, according to the Harris County Sheriff's Office.
Photos and video from the scene showed the cab of the 18-wheeler upside down on the shoulder of the freeway with the smashed trailer on the feeder road below.
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It's unclear what exactly led up to the crash.
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Authorities said one person was taken to the hospital.
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