Along with the expected AFC South rivals, they'll face teams from divisions including the AFC East and the NFC East.
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According to the Texans' website, 2018 will also see the return of the Dallas Cowboys and the New York Giants to NRG Stadium for the first time since the 2010 season.
Fans can buy the tickets online at ticketmaster.com or by phone at 1-800-745-3000.
Here's the full list of opponents at home and on the road.
Home Opponents:
Dallas Cowboys
New York Giants
Cleveland Browns
Buffalo Bills
Miami Dolphins
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Indianapolis Colts
Jacksonville Jaguars
Tennessee Titans
Road Opponents:
Washington Redskins
Philadelphia Eagles
Denver Broncos
New England Patriots
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New York Jets
Indianapolis Colts
Jacksonville Jaguars
Tennessee Titans
The full schedule for the Texans' regular season games can be found here.
HOME GAME THEMES:
-Aug. 18: State of Football presented by Verizon
-Aug. 30: Texans Care presented by Chevron
-Sept. 23: Liberty White Out presented by BHP
-Oct. 7: Pink Ribbon Day/NFL Crucial Catch presented by Kroger
-Oct. 14: Battle Red Day presented by Halliburton
-Oct. 25: Homecoming presented by Palais Royal
-Nov. 26: Salute to Service presented by Bud Light
-Dec. 2: Deep Steel Sunday presented by Hyundai
-Dec. 9: Kids Day - A Celebration of PLAY 60 presented by Texas Children's Hospital
-Dec. 30: Fan Appreciation Day
Related: The 5 defining moments of the 2017 Houston Texans
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