It happened around midnight in the 6000 block of Bissonnet near Rampart.
The victim and another man were getting into their car at a store when the gunmen ambushed them and opened fire, according to police.
One of the men was hit as they tried to runaway, police said. The other victim was not injured.
The shooters took off on foot, heading eastbound on Bissonnet.
The suspects were described as Hispanic males in their 20s.