The fight broke out in the middle of the fourth quarter after Los Angeles' player Brandon Ingram reportedly pushed Houston's James Harden after being called for a foul.
Things began heating up when Rajon Rondo and Chris Paul started arguing. Video from the game shows Paul placed his hand on Rondo's face, to which he responded with a punch.
Punches were thrown and then Ingram ran back from the half-court and threw a punch.
Paul claims Rondo initiated the fight by spitting on him.
There's no word what punishment the players could face.