It happened around 9 p.m. on Scott street near Barberry in Southeast Houston.
A 22-year-old man died from his injuries. The 2-year-old was shot in the leg, and in total, five people were shot.
Police said the party consisted of about 200 to 300 people.
"Five different weapons passed off, so trying to put it all together," said Commander Ron Borza.
Investigators said they were talking to one person of interest.
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