Houston police said officers responded to the fatal crash at about 3:21 p.m. at 4399 W. Tidwell Road.
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HPD Lt. Larry Crowson said a gray pickup truck and a black sedan were involved in the collision.
SkyEye flew over the scene, where the pickup could be seen flipped over in the middle of the road.
The pickup driver was taken to the hospital and is stable, Crowson said.
Two women who were in the sedan were both killed in the crash.
Crowson said the pickup driver showed no obvious signs of intoxication, but the investigation is ongoing.
The details of how the crash occurred are still unclear.
HPD said W. Tidwell would be closed in both directions as they investigate the incident.
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