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Deputies say the crash happened at about 2:05 a.m. at 11700 South Sam Houston Toll Road West on the eastbound lanes.
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The driver of a gray 2020 Toyota Rav4 crashed into the barrier of the toll road, veered into traffic, and crossed multiple lanes, according to investigators.
Deputies said the driver of a 1991 Chevy pickup truck crashed into the Toyota after trying to stop.
A wrecker driver tried to break the window of the Toyota to rescue the driver, but flames overcame the vehicle due to the crash.
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The driver of the Toyota died at the scene.
It's unclear if he died as a result of the crash or of the fire.
Investigators did not immediately disclose what caused the initial crash.