The crash, which involved three vehicles, happened in the 22400 block of Aldine Westfield Road near Hirschfield Road, close to the Mercer Botanic Gardens.
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Aldine Westfield Road was shut down in the area, but it has since been reopened in both directions.
It's unclear what exactly led up to the deadly crash or how many people were injured.
The Harris County Pct. 4 Constable's Office is investigating.
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