Keuchel, who was scratched from Wednesday's game against the Kansas City Royals, will be out due to neck discomfort.
The Astros called up Francis Martes, their top pitching prospect, from Triple-A Fresno. Martes is expected to pitch initially out of the bullpen for the Astros, ESPN reported.
Keuchel was placed on the disabled list last month because of a pinched nerve in his neck.
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