The fire reportedly happened on Sunday at 3599 Mcllhenny Street near Lucinda Street.
It was confirmed by Houston fire officials and neighbors on scene that there was a man trapped inside.
Neighbors in the area spoke to ABC13 and said they smelled smoke and attempted to save the man by smashing in a window and kicking down a door, but were unsuccessful.
The man trapped inside reportedly became disoriented and passed out, neighbors said.
When HFD arrived, a firefighter, not wearing any equipment, noticed the man on a bed and jumped through the window and pulled him through.
The man did not appeared to be burned, but did suffer severe smoke inhalation.
He was the only person inside the home at the time.
It was not immediately made known what caused the fire.