Texas Department of Public Safety is investigating the crash that happened just before 2 p.m.
"It's sad. It's horrific," Texas Department of Public Safety Sgt. Erik Burse said. "There's pieces of vehicles everywhere. You had two pieces of roadway that had to be shutdown. It's a main funnel from I-45 to FM 1314. So it was a mess."
A vehicle traveling west on the state highway lost its trailer load. The load then veered into eastbound traffic and struck another vehicle.
"When I pulled up I saw the trailer flipped over and the car that had the blanket on top of it and then I had another car behind it," witness, Marcus Jones recalled. "It's terrible, man."
The roadway was closed for three hours and reopened around 5 p.m.
DPS said a third vehicle was involved in the wreck.
Someone from that vehicle was taken to a nearby hospital with injuries.
Troopers said the truck driver wasn't hurt and was cooperative.
DPS said the driver wasn't cited as it investigates the crash.
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