Police have not released many details about what led up to the shooting.
Hempstead police say four people were shot outside a home on Lafayette near 4th Street just before 1 a.m.
It may have been a drive-by shooting, police say.
"We have four victims. I've got one that's shot in the leg," an officer said on a radio call for help.
One victim was flown to Memorial Hermann. He is said to in be stable condition.
Hempstead police told ABC13 they would provide an update at 8 a.m. For now, there is no suspect description.