The crash happened around 2:30 a.m. Wednesday in the 13000 block of Wallisville Road, between Normandy and Maxie.
[Ads /]
According to the Harris County Sheriff's Office, the 50-year-old driver of the semi was in the westbound lanes of Wallisville while the 29-year-old driver of a silver Toyota Corolla was in the eastbound lanes, when the Corolla crossed into the westbound side, in front of the H-E-B truck.
The Corolla driver died. He did not have any passengers.
Deputies say the semi driver showed no signs of impairment and had just dropped off a delivery at a nearby Joe V's, a discount grocery concept owned by H-E-B.
He is cooperating.
The sheriff's office said it was drizzling when deputies arrived, but they do not believe weather was a factor in the crash.
[Ads /]
The gas tank of the trailer was damaged in the crash, causing diesel fuel to leak onto the road.
Authorities plan to do a full investigation into whether the Corolla driver was impaired.
Follow Katherine Marchand on Facebook and Twitter.