According to a tweet posted by the singer, his team has advised him that the show "can't happen" due to weather.
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"Safety must take priority, so please go home and be safe," he wrote.
According to the Toyota Center's website, the show was slated to kick off at 8 p.m.
As Nicholas moves closer to the Texas coastline, officials across the Houston area have already told residents to plan to head somewhere safe indoors by 7 p.m. on Monday.
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Authorities said the possibility of flash flooding is their main concern.
Harris County Judge Lina Hidalgo issued a warning minutes before the singer canceled the show saying, "We cannot, in good conscience, advise folks to drive to and from the Harry Styles concert [Monday night.] It is simply going to be too dangerous of a situation on our roads. We don't want to lose people on our roads."
The former One Direction singer performed in San Antonio Sunday night.
A rescheduled date was not immediately released, but ticketholders are encouraged to monitor the Toyota Center's website for any updates.