Harris County Sheriff Ed Gonzalez said the crash happened in the 400 block of SH-99 W. Grand Parkway South.
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SkyEye video from above the scene shows a charred 18-wheeler on the roadway.
Shortly before 8 a.m. Gonzalez said on social media that the cleanup was expected to take around four hours.
It's unclear what led to the crash or if any injuries were reported.
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