The shooting happened at about 6:10 p.m. in the 2100 block of Mid Lane. According to HPD Chief Troy Finner, officers responded to the scene and found the victim dead.
Witnesses told police the unidentified victim, described as a Black man in his 20s, was driving a white Mercedes, when the suspects drove up in a black Subaru vehicle. Multiple shots were fired, and then two suspects got out of the vehicle and fled on San Felipe in an unknown direction.
Given the number of bullet casings at the scene, police believe this was a targeted incident. Officers are still looking at surveillance cameras but are also asking anyone with information to come forward.
The identity of the victim was not immediately released.
The only description police said they have of the suspects is that they were all dressed in black, with hoodies, and had shades on.
According to ABC13's Neighborhood Safety Tracker, this area has among the lowest murder rates in the city. The data shows there was one murder in the last 12 months.
For updates on this story, follow Daniela Hurtado on Facebook, Twitter and Instagram.