She had five girls in the vehicle, according to Harris County deputies.
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It happened in the 3200 block of Greenhouse Road near Morton around 8:40 p.m. Friday.
The 35-year-old woman was driving northbound in a 2012 Chevrolet Tahoe when she ran a red light, deputies said. That's when she crashed into a Toyota Corolla driven by a 56-year-old man on Morton Road.
The Tahoe ended up striking a tree in the median.
The woman, a 13-year-old and the 5-year-old were taken by Life Flight to a hospital and were stable. The man was also stable at a local hospital, deputies said.
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The girls told deputies she was drinking from a vodka bottle, and the woman confirmed, according to HSCO.
Deputies said charges were pending.