The fire broke out at about 5 a.m. When firefighters arrived, they said they saw the fire coming through the roof.
Video from Houston TranStar cameras shows the building completely engulfed in flames.
The building, located right off 290 near Bingle Road, used to be NW Dental, though it has since been abandoned, Houston Fire Department District Chief Tim Vatuna said.
Houston fire officials said an arson team is investigating what may have sparked the flames.
No firefighters or civilians were injured.
The fire forced the feeder road to close at Bingle. There was also a crash reported just south of the fire on 290.
The feeder road has since reopened.