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The shooting happened shortly after 5 p.m. in the 4900 block of Lockwood near Pardee Street.
According to detectives, a driver in a pickup truck and another in an SUV were involved in a disturbance near the area.
The driver of the pickup truck then pulled into a nearby tire shop, where the other driver in the SUV followed, shot him, and fled the scene.
Detectives say the victim, who died on the scene, was a man in his 50s.
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According to detectives, officers found the suspect's vehicle a few blocks from the scene.
Officials did not elaborate on a suspect description.