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The Houston Police Department said the wreck happened at about 11:45 a.m. in the 8700 block of Sterlingshire Street near Mesa Drive.
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Police said one person was killed in the crash but haven't identified the victim.
SkyEye flew over the scene, where a damaged motorcycle could be seen lying on the road.
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HPD has not said how the crash unfolded.
Drivers are asked to avoid the area as the investigation continues.