All mainlanes of I-10 were shut down eastbound between McCarty and Mercury for hours. The freeway has since reopened.
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Witnesses told police the teen was in the driver's seat of his disabled Mazda when his car was struck from behind by a black Jeep Wrangler.
The victim was taken to Memorial Hermann Hospital, where he was pronounced dead.
A woman who was driving the Jeep Wrangler did not show signs of impairment, according to police, and was taken to St. Joseph Medical Center with non-life threatening injuries.
SkyEye13 was over the incident, where you could see the Jeep slammed into the back of the Mazda.
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Police said they are continuing their investigation into the crash. The names of the victim and the Jeep's driver have not been released.
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