Houston police said the incident happened at about 10:50 a.m. at 4900 Fannin St.
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HPD said it all started when an 80-year-old man driving a white GMC Jimmy was going southbound on Fannin when he ran the red light at the intersection of Wichita.
A blue Volvo XC60, which had a green light, entered the intersection and hit the GMC, causing the truck to roll over and eject its driver, according to police.
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Paramedics responded to the scene and pronounced the driver of the GMC dead. The driver of the Volvo was reportedly not injured.
Officials said the identity of the 80-year-old man is pending verification by the Harris County Institute of Forensic Sciences.
This is an ongoing investigation.