It happened around 3 a.m. at Southwest Freeway and Bissonnet.
The victim was southbound on the feeder road at a high rate of speed when the driver ran a red light and slammed into the SUV, according to Houston police.
The impact of the crash sent the car into a concrete pillar under the freeway bridge.
The driver died at the scene, police said.
A passenger inside the car was taken to a hospital where they were stable.
The driver and passenger inside the SUV were also hospitalized and were stable.
The victim's identity wasn't immediately released.