Deputies responded to the 16000 block of Avenue D to a trailer home just after 10 p.m. on Thursday.
Upon arrival, a 51-year-old and a 47-year-old man were found dead from what appeared to be stab wounds, according to HCSO.
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Officials learned that a woman who called 911 had just moved into the area three or four days prior and lived with one of the victims. Officials said she called over the second victim, who was reported to be her friend.
An altercation ensued between the men, who were both said to have had knives, according to Sgt. Greg Pinkins with HCSO homicide.
Investigators said they believe there was no known relationship between the two men.
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There is a report of a woman and young child who allegedly left the residence before HCSO deputies arrived, but investigators have not confirmed that, Pinkins said.
This is an ongoing investigation, officials said.