The crash happened at about 9 p.m. on Airtex Road in the northbound lanes of I-45.
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Units with the Harris County Sheriff's Office arrived at the scene and discovered two vehicles that crashed.
A preliminary investigation found the driver operating a 1996 Ford Crown Victoria had a flat tire and was moving slowly in the far left lane before being rear-ended by a man driving a 2006 Honda Accord.
Officials said the 50-year-old man driving the Accord had his 4-year-old grandson in the backseat.
HCSO said the impact caused the Ford to spin counter-clockwise several times and create sparks that ignited into flames, trapping the driver.
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EMS arrived on the scene and pronounced the Ford's driver dead.
All northbound lanes near Airtex were closed until 3 a.m. Saturday morning.
The 50-year-old man and his grandson were transported to Memorial Hermann with non-life-threatening injuries.
Officials said the 50-year-old showed no signs of intoxication.
This incident remains under investigation by the Harris County Sheriff's Office Vehicular Crimes Division.