The crash happened just before 2 p.m. in the 151000 block of Crosby Freeway near Miller Road.
According to Sheriff Ed Gonzalez, deputies with Precinct 3 began a pursuit of the motorcycle rider but quickly terminated the chase.
Officials said the man continued driving on, but crashed into the truck.
Officials did not expand on additional details as to why deputies initially began the chase.
The rider was pronounced dead at the scene.
As the investigation continues, officials said Crosby Freeway's eastbound feeder road will close for at least two hours.
This is a developing story. ABC13 has a crew en route to uncover more information.